Pathophysiology of Acute Gastroenteritis [PDF]

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Pathophysiology of Acute Gastroenteritis Precipitating Factors • Contaminated food and water



Predisposing Factors • Age • Malnutrition Ingestion of fecally contaminated food & water Direct invasion of the bowel wall



Endotoxins are released



Stimulation and destruction of mucosal lining of the bowel wall



Attempted defecation (Tenesmus)



Digestive & absorptive malfunction



Excessive gas formation



Increase peristaltic movement



GI Distention Mild Diarrhea (2-3 Stools)



Nausea & Vomiting Fluids & Electrolytes Imbalance



Increased protein in the lumen



LI is overwhelmed & unable to reabsorb the lost fluid



Intense Diarrhea (>10x) (Watery Stool)



Serious Fluid Volume Deficit



If untreated... Hypovolemic Shock



Death



Secretion of F&E in the intestinal lumen