Tabel Dosis Nicardipine: Pelarut/Cairan Infus Yang Dapat Digunakan [PDF]

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TABEL DOSIS NICARDIPINE Perdipine ® injeksi Indika 1 Ampul 10 mg si Dalam larutan 50 cc Berat (cc/jam) Badan 40 Kg Atau 50 Kg Perdipine ® injeksi 2 Ampul 10 mg Dalam larutan 100 cc (tetes/menit mikrodrip)



DOSIS PERDIPINE ® INJEKSI (µg/kgBB/menit) HIPERTENSI EMERGENSI KRISIS HIPERTENSI AKUT SELAMA OPERASI 10,0 2,0 3,0 4,0 5,0 6,0 7,0 8,0 9,0 0 24 36 48 60 72 84 96 108 120



0,5



1,0



1,5



6



12



18



7,5



15



22,5



30



45



60



75



90



105



120



135



150



9



18



27



36



54



72



90



108



126



144



162



180



70 Kg 10,5



21



31,5



42



63



84



105



126



147



168



189



210



80 Kg



24



36



48



72



96



120



144



168



192



216



240



27



41



54



81



108



135



162



189



216



243



270



60 Kg



12



90 Kg 13,5



PELARUT/CAIRAN INFUS YANG DAPAT DIGUNAKAN : NaCI 0,9%, Dextrose 5%, Patacol-R, Glucose 5%, Ringer Asetat, KN Solution



DOSIS PEMBERIAN INOTROPIK DALAM SYRING PUMP NOREPINEPHRINE 4 mg Dosis µg/Kg



KECEPATAN SYRING PUMP (cc/jam) BB 40



BB 50



BB 60



BB 70



BB 80



0,1



3



3,8



4,5



5,3



6



0,2



6



7,5



9



10,5



12



0,3



9



11,3



13,5



15,8



18



0,4



12



15



18



21



24



0,5



15



18,8



22,5



26,3



30



0,6



18



22,5



27



31,5



36



0,7



21



26,3



31,5



36,8



42



0,8



24



30



36



42



48



0,9



27



33,8



40,5



47,



54



1



30



37,5



45



52,5



60



NOREPINEPHRINE 1 mg/ml



RAIVAS INFUSION CHART



1 ampul RAIVAS dilarutkan dalam 50 cc NaCl 0.9% atau Dextrose 5% Konsentrasi larutan Norepinephine 80 mcg/ml pelarut Dosage mcg/kgBB/min 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 0.45 0.50



Flow rate (cc/hour) 1.50 3.00 4.50 6.00 7.50 9.00 10.50 12.00 13.50 15.00



1.69 3.38 5.10 6.75 8.44 10.13 11.81 13.50 15.19 16.88



1.88 3.75 5.63 7.50 9.38 11.25 13.13 15.00 16.88 18.75



2.06 4.13 6.19 8.25 10.31 12.38 14.44 16.50 18.56 20.63



2.25 4.50 6.75 9.00 11.25 13.50 15.75 18.00 20.25 22.50



2.44 4.88 7.31 9.75 12.19 14.63 17.06 19.50 21.94 24.38



2.63 5.25 7.88 10.50 13.13 15.75 18.38 21.00 23.63 26.25



2.81 5.63 8.44 11.25 14.06 16.88 19.69 22.50 25.31 28.13



0.55 0.60 3.65 0.70 0.75 0.80 0.85 0.90 0.95 1.00



16.50 18.00 19.50 21.00 22.50 24.00 25.50 27.00 28.50 30.00



118.56 20.25 21.94 23.63 25.31 27.00 28.69 30.38 32.06 33.75



20.63 22.50 24.38 26.25 28.14 30.00 31.88 33.75 35.63 37.50



22.69 24.75 26.81 28.88 30.94 33.00 35.06 37.13 39.19 41.25



24.75 27.00 29.25 31.50 33.75 36.00 38.25 40.50 42.75 45.00



26.81 29.25 31.69 34.13 36.56 39.00 41.44 43.88 46.31 48.75



28.88 31.50 34.13 36.75 39.30 42.00 44.63 47.25 49.88 52.50



30.94 33.75 36.56 39.38 42.19 45.00 49.81 50.63 53.44 56.25



1.05 1.10 1.15 1.20 1.25 1.30 1.35 1.40 1.45 1.50



31.50 33.00 34.50 36.00 37.50 39.00 40.50 42.00 43.50 45.00



35.44 37.15 38.81 40.50 42.19 43.88 45.56 47.25 48.94 50.63



39.38 41.25 43.13 45.00 46.88 48.75 50.63 52.50 54.38 56.25



43.31 45.38 47.44 49.50 51.56 53.63 55.69 57.75 59.81 61.88



47.25 49.50 51.75 54.00 56.25 58.50 60.75 63.00 65.25 67.50



51.19 53.63 56.06 58.50 60.94 63.38 65.81 68.25 70.69 73.13



55.13 57.75 60.38 63.00 65.63 68.25 70.88 73.50 76.13 78.75



59.06 61.88 64.69 67.50 70.31 73.13 75.94 78.75 81.56 84.38



1.55 1.60 1.65 1.70 1.75 1.80 1.85 1.90 1.95 2.00 Body Weight (kg)



46.50 48.00 49.50 51.00 52.50 54.00 55.50 57.00 58.50 60.00 40



52.31 54.00 55.69 57.38 59.06 60.75 62.44 64.13 65.81 67.50 45



58.13 60.00 61.88 63.75 65.63 67.50 69.38 71.25 73.13 75.00 50



63.94 66.00 68.06 70.13 72.19 74.25 76.36 78.38 80.44 82.50 55



69.75 72.00 74.25 76.50 78.75 81.00 83.25 85.50 87.75 90.00 60



75.56 78.00 80.44 82.88 85.30 87.75 90.19 92.63 95.06 97.50 65



81.38 84.00 86.63 89.25 91.88 94.50 97.13 99.75 102.38 105.00 70



87.19 90.00 92.81 95.63 98.44 101.25 104.06 106.88 109.69 112.50 75



Dopamine



: 5 - 20 mcg



Dobutamine



: 5 - 20 mcg



Vascon



: 0,05 - 2 mcg



1) * diubah dari miligram (mg) menjadi mikrogram (mcg), dalam sediaan : Dopamin



: 200 mg  200.000 mcg



Dobutamin



: 250 mg  250.000 mcg



Norepinephrine



: 4 mg  4.000 mcg



2) * rumus penecer Biasanya pengencer yang dipakai water injection 50 cc “banyaknya pengecer : sediaan dalam micro gram” Dopamin



200 000 : 50 = 4000



Dobutamin



250 000 : 50 = 5000



Norepinephrine



4000 : 50 = 80



3) *rumus perhitungan dosis yang masuk ke dalam tubuh per jam = dosis yang diminta oleh dokter x BB pasien x 60 menit Pengecer Contoh : diminta dopamine 6 mcg dengan pengecer 50 cc, BB pasien 50kg, hitung dosis! = 6 mcg x 50 x 60 4000 = 4,5 ml/jam



NITROGLYCERIN (1 ampul=50mg) Dosing : (HTN/CHF/Angina) : initial infusion rate 5 mcg/min. May increase by 5 mcg/min every 3 to 5 minutes until response. If 20 mcg/minute is inadequate, increase by 10 to 20 mcg/min every 3 to 5 minutes. (maximum dose : 400 mcg/minute) Calculation of drip rate (50 mg / 250 ml) ml/hr = mcg / min x 0.3 (eg 5 mcg/min = @ 2ml/hr ; 20 mcg/min = 6 ml/hr etc.) Solution Concentration (ml) Dose (mcg/min) 5 10 15 20 30 40 60 80 120 160 240 320 480



50 100 FLOW RATE (cc/hr) 1.5 3 3 6 4.5 9 6 12 9 18 12 24 18 36 24 48 36 72 48 96



DOBUTAMIN 250 mg PENGENCERAN 250 mg/50 mg Dosis : 1 – 20 mcg/kgBB/menit Rumus : Dosis x Berat Badan x Menit Pengenceran Berat badan



Dosis 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20



30



35



40



0.36 0.72 1.08 1.44 1.8 2.16 2.52 2.88 3.24 3.6 3.96 4.32 4.68 5.04 5.4 5.76 6.12 6.48 6.84 7.2



0.42 0.84 1.26 1.68 2.1 2.52 2.94 3.36 3.78 4.2 4.62 5.04 5.46 5.88 6.3 6.72 7.14 7.56 7.98 8.4



0.48 0.96 1.44 1.92 2.4 2.88 3.36 3.84 4.32 4.8 5.28 5.76 6.24 6.72 7.2 7.68 8.16 8.64 9.12 9.6



Kecepatan cc/jam 45 50 0.54 1.08 1.62 2.16 2.7 3.24 3.78 4.32 4.86 5.4 5.94 6.48 7.02 7.56 8.1 8.64 9.18 9.72 10.26 10.8



0.6 1.2 1.8 2.4 3 3.6 4.2 4.8 5.4 6 6.6 7.2 7.8 8.4 9 9.6 10.2 10.8 11.4 12



55



60



65



70



0.66 1.32 1.98 2.64 3.3 3.96 4.62 5.28 5.94 6.6 7.26 7.92 8.58 9.24 9.9 10.56 11.22 11.88 12.54 13.2



0.72 1.44 2.16 2.88 3.6 4.32 5.04 5.76 6.48 7.2 7.92 8.64 9.36 10.08 10.08 11.52 12.24 12.96 13.68 14.4



0.78 1.56 2.34 3.12 3.9 4.68 5.46 6.24 7.02 7.8 8.58 9.36 10.14 10.92 11.7 12.48 13.26 14.04 14.82 15.6



0.84 1.68 2.52 3.36 4.2 5.04 5.88 6.72 7.56 8.4 9.24 10.08 10.92 11.76 12.6 13.44 14.28 15.12 15.96 16.8



Tabel Dosis DOPAMIN / kgBB Dosis (mcg/kgBB/mnt) 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Berat Badan (Kg)



1,2 1,8 2,4 3 3,6 4,2 4,8 5,4 6 6,6 7,2 7,8 8,4 9 9,6 10,2 10,8 11,4 12



1,4 2 2,7 3,4 4,1 4,7 5,4 6,1 6,8 7,4 8,1 8,8 9,5 10,1 10,8 11,5 12,2 12,8 13,5



1,5 2,3 3 3,8 4,5 5,3 6 6,8 7,5 8,3 9 9,8 10,5 11,3 12 12,8 13,5 14,3 15



40



45



50



Kecepatan cc/jam 1,7 2,5 3,3 4,1 5 5,8 6,6 7,4 8,3 9,1 9,9 10,7 11,6 12,4 13,2 14 14,9 15,7 16,5



1,8 2,7 3,6 4,5 5,4 6,3 7,2 8,1 9 9,9 10,8 11,7 12,6 13,5 14,4 15,3 16,2 17,1 18



2 2,9 3,9 4,9 5,9 6,8 7,8 8,8 9,8 10,7 11,7 12,7 13,7 14,6 15,6 16,6 17,6 18,5 19,5



2,1 3,2 4,2 5,3 6,3 7,4 8,4 9,5 10,5 11,6 12,6 13,7 14,7 15,8 16,8 17,9 18,9 20 21



2,3 2,3 3,4 4,5 5,6 6,8 7,9 9 10,1 11,3 12,4 13,5 14,6 15,8 16,9 18 19,1 20,3 21,4



55



60



65



70



75



Kemasan 1 ampul = 5 ml = 200 mg = 200.000 mcg (1 amp dimasukan dlm 40 cc) Rumus



DosisxKgBBx60 mnt Penegcer (4000)



= …. ml/jam = ….. tpm microdrip



AMIODARONE Stable Monomorphic or Polymorphic Ventricular Tachycardia (Off-label) 150 mg IV bolus in 10 minutes; may repeat q10min as necessary, THEN 1mg/min IV for 6 hours, THEN 0.5 mg/min IV for 18 hours; not to exceed 2.2 g/24hr For breakthrough episodes of VF or hemodynamically unstable VT, repeat the initial load Dosing considerations  Intiate in hospital with experienced personel ACLS, Pulseless Ventricular Fibrillation/Ventricular Tachycardia (Off-label) 300mg IV or intraosseous push after dose epinephrine if no initial response to defibrillation May follow initial dose with 150 mg IV q3-5min Dosing considerations  Rapid IV push if pulseless/no BP Ventricular Arrhythmias PO



IV



 Load : 800-1600 mg PO qDay for 1-3 weeks until response: once adequate arrhythmia control achieved, reduce dose to 600-800 mg/day for 1 mo; THEN reduce to maintenance dose  Maintenance dose : 400 mg PO qDay  150 mg over first 10 min (15mg/min), followed by 360 mg over next 6 hr (1 mg/min), THEN 540 mg over remaining 18 hr (0.5 mg/min, for a total of 1000 mg over 24 hr before administering maintenance infusion  Maintenance: 0.5 mg/min for a total 720 ng/24 hr at a concentration of 1-6 mg/mL (360 mg/200mL), or 1.8 mg/mL Nexterone at rate of 278 mL/min  Duration of therapy: May continue to administer 0.8 mg/min for 2-3 weeks regardless of patient’s age, renal function or ventricular finction