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KAJIAN PENDAHULUAN FORMULASI SEDIAAN KRIM BEDAK DINGIN TRADISIONAL
SKRIPSI
Diajukan untuk memenuhi salah satu syarat mencapai gelar Sarjana Sains(S.Si) Program Studi Farmasi pada Fakultas Matematika dan Ilmu PengetahuanAlam Universitas Islam Indonesia
Yogyakarta
Oleh: AYU PUSPITASARI No. Mhs 99613152 NIRM 990051012807120148
JURUSAN FARMASI
FAKULTAS MATEMATIKA DAN ILMU PENGETAHUAN ALAM UNIVERSITAS ISLAM INDONESIA YOGYAKARTA
2003
KAJIAN PENDAHULUAN FORMULASI SEDIAAN KRIM BEDAK DINGIN TRADISIONAL
SKRIPSI
Diajukan untuk memenuhi salah satu syarat mencapai gelar sarjana (S.Si) Program Studi Farmasi pada Fakultas Matematika dan Ilmu Pengetah Alam Universitas Islam Indonesia
Yogyakarta
Disusun oleh:
Ayu Puspitasari 99613152
Disetujui oleh:
Pembimbing I
Pembimbing II
/frur'
i \)
Dra. Mimiek Murrukmihadi S.U., Apt
Maryanto S.Si., Apt.
JURUSAN FARMASI FAKULTAS MATEMATIKA DAN ILMU PENGETAHUAN ALAM UNIVERSITAS ISLAM INDONESIA 2003
LEMBAR PENGESAHAN PENGUJI
Berjudul KAJIAN PENDAHULUAN FORMULASI SEDIAAN KRIM BEDAK DINGIN TRADISIONAL Oleh AYU PUSPITASARI
No. Mhs
99613152
NIRM 990051012807120148
Telah dipertahankan dihadapan Panitia Penguji Skripsi Jurusan Farmasi Fakultas Matematika dan Ihnu Pengetahuan Alam Universitas Islam Indonesia
Tangggal: .. \.'.4f NM* &I..'. ^QO^ Penguji
Tanda tangan
1. Dra. Mimiek Murrukmihadi S.U., Apt.
^-""Y
2. Maryanto S.Si., Apt.
^
3. Yandi Sukri M.Si., Apt
Dekan F;
Mengetahui dan Ilmu Pengetahuan Alam Indonesia
PERNYATAAN
Dengan ini saya menyatakan bahwa dalam tesis ini tidak terdapat karya yang pernah diajukan untuk memperoleh gelar kesarjanaan di suatu perguruan tinggi
dan sepanjang pengetahuan saya juga tidak terdapat karya atau pendapat yang pernah ditulis atau diterbitkan oleh orang lain, kecuali yang secara tertulis diacu dalam naskah ini dan diterbitkan dalam daftar pustaka.
Yogyakarta, 29 Desember 2003 Penulis
Ayu Puspitasari
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so : Nilai Daya.Sebar 95% Confidence Interval Kadar Bedak
Mean
Std. Error
Lower Bound
Upper Bound
Kadar Bedak 5%
6.789
.111
6.565
7.013
kadar bedak 10%
6.714
.111
6.490
6.938
kadar bedak 15%
6.004
.111
5.780
6.228
kadar bedak 20%
5.097
.111
4.873
5.321
kadar bedak 25%
4.311
.111
4.087
4.535
2. Lama Penyimpanan
DependentVariable: Nilai DayaSebar 95% Confidence Interval
Lama Penyimpanan minggu 1 minggu 2 minggu 3 minggu 4
Std. Error
Lower Bound
Upper Bound
6.358
.099
6.158
6.559
6.042
.099
5.842
6.242
5.501
.099
5.301
5.702
5.230
.099
5.029
5.430
Mean
3. Kadar Bedak * Lama Penyimpanan
Dependent Variable: Nilai Daya Sebar 95% Confidence Interval
Kadar Bedak Kadar Bedak 5%
kadarbedak 10%
kadarbedak 15%
kadar bedak 20%
kadar bedak 25%
Lama Penyimpanan minggu 1
Mean
Upper Bound
Std. Error
Lower Bound
7.545
.222
7.097
7.993
minggu 2
7.066
.222
6.618
7.514
minggu 3
6.603
.222
6.155
7.051
minggu 4
5.942
.222
5.494
6.390
minggu 1
7.223
.222
6.775
7.671
minggu 2 minggu 3
7.152
.222
6.704
7.600
6.538
.222
6.090
6.987
minggu 4
5.942
.222
5.494
6.390
minggu 1
7.228
.222
6.780
7.677
minggu 2
6.231
.222
5.783
6.679
minggu 3
5.247
.222
4.799
5.696
minggu 4
5.308
.222
4.860
5.756
minggu 1 minggu 2 minggu 3
5.457
.222
5.009
5.906
5.173
.222
4.725
5.622
4.782
.222
4.333
5.230
minggu 4
4.975
.222
4.527
5.423
minggu 1
4.337
.222
3.888
4.785
minggu 2
4.588
.222
4.139
5.036
minggu 3
4.337
.222
3.888
4.785
minggu 4
3.982
.222
3.533
4.430
Lampiran 6
42
Uji Tukey HSD Untuk Uji Daya Sebar Post Hoc Tests Kadar Bedak Multiple Comparisons
Dependent Variable: Nilai Daya Sebar Tukev HSD
Mean 95% Confidence Interval
Difference
(1) Kadar Bedak
(J) Kadar Bedak
Kadar Bedak 5%
kadar bedak 10%
.07517
.156839
.989
-.37278
.52311
kadar bedak 15%
.78533*
.156839
.000
.33739
1.23328
kadar bedak 10%
kadar bedak 25%
Sig.
Lower Bound
Upper Bound
kadar bedak 20%
1.69217*
.156839
.000
1.24422
2.14011
2.47833*
.156839
.000
2.03039
2.92628
Kadar Bedak 5%
-.07517
.156839
.989
-.52311
.37278
.71017*
.156839
.000
.26222
1.15811
kadar bedak 20%
1.61700*
.156839
.000
1.16905
2.06495
kadar bedak 25%
2.40317*
.156839
.000
1.95522
2.85111
Kadar Bedak 5%
-.78533*
.156839
.000
-1.23328
-.33739
kadar bedak 10%
-.71017*
.156839
.000
-1.15811
-.26222
kadar bedak 20%
.90683*
.156839
.000
.45889
1.35478
kadar bedak 25% kadar bedak 20%
Std. Error
kadar bedak 25%
kadar bedak 15%
kadar bedak 15%
(l-J)
1.69300*
.156839
.000
1.24505
2.14095
Kadar Bedak 5%
-1.69217*
.156839
.000
-2.14011
-1.24422
kadar bedak 10%
-1.61700*
.156839
.000
-2.06495
-1.16905
kadar bedak 15%
-.90683*
.156839
.000
-1.35478
-.45889
kadar bedak 25%
.78617*
.156839
.000
.33822
1.23411
Kadar Bedak 5%
-2.47833*
.156839
.000
-2.92628
-2.03039
kadar bedak 10%
-2.40317*
.156839
.000
-2.85111
-1.95522
kadar bedak 15%
-1.69300*
.156839
.000
-2.14095
-1.24505
kadar bedak 20%
-.78617*
.156839
.000
-1.23411
-.33822
Based on observed means.
*• The mean difference is significant at the .05 level.
Lampiran 6 (Lanjutan)
43
Homogeneous Subsets Nilai Daya Sebar
Tukey HSCP'b Subset
Kadar Bedak kadar bedak 25%
N
1 12
kadar bedak 20%
12
kadar bedak 15%
12
kadar bedak 10%
12
Kadar Bedak 5%
12
Sig.
2
3
4
4.31067 5.09683 6.00367 6.71383 6.78900 1.000
1.000
1.000
.989
Means for groups in homogeneous subsets are displayed. Based on Type III Sum of Squares The error term is Mean Square(Error) = .148. a. Uses Harmonic Mean Sample Size = 12.000.
b. Alpha = .05.
Lama Penyimpanan Multiple Comparisons
Dependent Variable: Nilai Daya Sebar Tukey HSD Mean 95% Confidence Interval
Difference
(I) Lama Penyimpanan minggu 1
minggu 2
minggu 3
minggu 4
(J) Lama Penyimpanan minggu 2
(l-J)
Std. Error
Sig.
Lower Bound
Upper Bound
.31607
.140281
.127
-.05995
.69208
minggu 3
.85667*
.140281
.000
.48065
1.23268
minggu 4 minggu 1 minggu 3 minggu 4 minggu 1 minggu 2 minggu 4 minggu 1
1.12833*
.140281
.000
.75232
1.50435
-.31607
.140281
.127
-.69208
.05995
.54060*
.140281
.002
.16459
.91661
.81227*
.140281
.000
.43625
1.18828
-.85667*
.140281
.000
-1.23268
-.48065
-.54060*
.140281
.002
-.91661
-.16459
.27167
.140281
.229
-.10435
.64768
-1.12833*
.140281
.000
-1.50435
-.75232
minggu 2
-.81227*
.140281
.000
-1.18828
-.43625
minggu 3
-.27167
.140281
.229
-.64768
.10435
ased on observed means.
* The mean difference is significant at the .05 level.
IMmpiran 6 (Ixmjutan)
44
Homogeneous Subsets Nilai Daya Sebar
Tukey HSD313 Subset
Lama Penyimpanan
2
1
N
minggu 4
15
5.22973
minggu 3
15
5.50140
minggu 2
15
minggu 1
15
Sig.
6.04200
6.35807 .229
.127
Means for groups in homogeneous subsets are displayed. Based on Type III Sum of Squares The error term is Mean Square(Error) = .148. a Uses Harmonic Mean Sample Size = 15.000.
b. Alpha = .05.
Lampiran 7
45
Anova Dua Jalan Untuk Uji Daya Lekat
Univariate Analysis of Variance Between-Subjects Factors Value Label Kadar Bedak
1.00
N
Kadar 12
Bedak 5% 2.00
Kadar
12
Bedak10% 3.00
Kadar
12
Bedak15% 4.00
Kadar
12
Bedak 20% 5.00
Kadar 12
Bedak 25%
Lama
1.00
Penyimpanan
2.00 3.00 4.00
Minggu 1 Minggu 2 Minggu 3 Minggu 4
15 15
15 15
Levene's Test of Equality of Error Variances Dependent Variable: Nilai Daya Lekat df1 1.025
df2 19
.SjJL 40
.457
Tests the null hypothesis that the error variance of the dependent variable is equal across groups.
a- Design: lntercept+FAKTOR_A+FAKTOR_B+FAKTOR_A *FAKTOR B
Tests of Between-Subjects Effects Dependent Variable: Nilai Daya Lekat
Type III Sum Source
Corrected Model
Intercept FAKTOR_A FAKTOR_B
of Squares 4.218a
Mean Square
df
Siq.
F
19
.222
7.668
60.060
1
60.060
2074.612
.000
3.060
4
.765
26.425
.000
.000
.946
3
.315
10.892
.000
.212
12
.018
.610
.821
Error
1.158
40
.029
Total
65.436
60
5.376
59
FAKTOR_A * FAKTOR_B
Corrected Total
a- R Squared= .785 (Adjusted RSquared = .682)
Lampiran 7 (Lanjutan)
46
Estimated Marginal Means 1. Kadar Bedak
Dependent Variable: Nilai Daya Lekat 95% Confidence Interval Kadar Bedak
Mean
Std. Error
Lower Bound
Upper Bound
Kadar Bedak 5%
.732
.049
.632
.831
Kadar Bedak 10%
.865
.049
.766
.964
Kadar Bedak 15%
.917
.049
.818
1.017
Kadar Bedak 20%
1.105
.049
1.006
1.204
.049
1.284
1.483
Kadar Bedak 25%
1.383
2. Lama Penyimpanan Dependent Variable: Nilai Daya Lekat 95% Confidence Interval
Lama Penyimpanan Minggu 1
Upper Bound
Std. Error
Lower Bound
.863
.044
.775
.952
Minggu 2
.901
.044
.812
.989
Minggu 3
1.063
.044
.975
1.152
Minggu 4
1.175
.044
1.086
1.263
Mean
3. Kadar Bedak * Lama Penyimpanan Dependent Variable: Nilai Daya Lekat 95% Confidence Interval Kadar Bedak
Lama Penyimpanan
Kadar Bedak 5%
Minggu 1
Kadar Bedak 10%
Kadar Bedak 15%
Kadar Bedak 20%
Kadar Bedak 25%
Upper Bound
Std. Error
Lower Bound
.547
.098
.348
.745
Minggu 2
.597
.098
.398
.795
Minggu 3 Minggu 4
.920
.098
.721
1.119
.863
.098
.665
1.062
Minggu 1
.730
.098
.531
.929
Minggu 2
.873
.098
.675
1.072
Minggu 3 Minggu 4
.857
.098
.658
1.055
1.000
.098
.801
1.199
Minggu 1
.780
.098
.581
.979
Minggu 2
.813
.098
.615
1.012
Mean
Minggu 3
1.020
.098
.821
1.219
Minggu 4
1.057
.098
.858
1.255
Minggu 1
1.053
.098
.855
1.252
Minggu 2
.963
.098
.765
1.162
Minggu 3
1.067
.098
.868
1.265
Minggu 4
1.337
.098
1.138
1.535
Minggu 1
1.207
.098
1.008
1.405
Minggu 2 Minggu 3 Minggu 4
1.257
.098
1.058
1.455
1.453
.098
1.255
1.652
1.617
.098
1.418
1.815
