Lampiran 4 CLSI [PDF]

Citation preview

53 Lampiran 6



Tabel Clinical and Laboratory Standards Institute (CLSI) Tahun 2012 A.



Staphylococcus sp Antibiotik



Penicillin Oxacillin (untuk S. aureus dan S. lugdunensis) Ampicillin Methicillin Nafcillin Amoxicillin-clavulanic acid Ampicillin-sulbactam Piperacillin-tazobactam Ticarcillin-clavulanic acid Cefamandole Cefazolin Cefepime Cefmetazole Cefonicid Cefoperazone Cefotaxime Cefotetan Ceftazidime Ceftizoxime Ceftriaxone Cefuroxime (parenteral) Cephalothin Moxalactam Cefacior Cefdinir Cefpodoxime Cefprozil Cefuroxime (oral) Loracarbef Doripenem Ertapenem Imipenem Meropenem Teicoplanin Gentamicin Amikacin Kanamycin Netilmicin Tobramycin Azithromycin Clarithromycin



Kriteria Penafsiran Diameter Zona (mm) Sensitif Intermediet Resisten ≥ 29 ≤ 28 ≥ 13 11-12 ≤ 10 ≥ 29 ≥ 14 ≥ 13 ≥ 20 ≥ 15 ≥ 18 ≥ 23 ≥ 18 ≥ 18 ≥ 18 ≥ 16 ≥ 18 ≥ 21 ≥ 23 ≥ 16 ≥ 18 ≥ 20 ≥ 21 ≥ 18 ≥ 18 ≥ 23 ≥ 18 ≥ 20 ≥ 21 ≥ 18 ≥ 23 ≥ 18 ≥ 30 ≥ 19 ≥ 16 ≥ 16 ≥ 14 ≥ 15 ≥ 17 ≥ 18 ≥ 15 ≥ 15 ≥ 18 ≥ 18



10-13 11-12 12-14 15-17 15-17 15-17 13-15 15-17 16-20 15-22 13-15 15-17 15-19 14-20 15-17 15-17 15-22 15-17 17-19 18-20 15-17 15-22 15-17 16-18 14-15 14-15 11-13 13-14 15-16 14-17 13-14 13-14 14-17 14-17



≤ 28 ≤9 ≤ 10 ≤ 19 ≤ 11 ≤ 17 ≤ 22 ≤ 14 ≤ 14 ≤ 14 ≤ 12 ≤ 14 ≤ 15 ≤ 14 ≤ 12 ≤ 14 ≤ 14 ≤ 13 ≤ 14 ≤ 14 ≤ 14 ≤ 14 ≤ 16 ≤ 17 ≤ 14 ≤ 14 ≤ 14 ≤ 15 ≤ 13 ≤ 13 ≤ 10 ≤ 12 ≤ 14 ≤ 13 ≤ 12 ≤ 12 ≤ 13 ≤ 13



54 Erythromycin Telithromycin Dirithromycin Tetracycline Doxycycline Minocycline Ciprofloxacin Levofloxacin Ofloxacin Moxifloxacin Lomefloxacin Norfloxacin Enoxacin Gatifloxacin Grepafloxacin Sparfloxacin Fleroxacin Nitrofurantoin Clindamycin Trimethoprim-sulfamethoxazole Sulfonamides Trimethoprim Chloramphenicol Rifampin Quinupristin-dalfopristin Linezolid



B.



≥ 23 ≥ 22 ≥ 19 ≥ 19 ≥ 16 ≥ 19 ≥ 21 ≥ 19 ≥ 18 ≥ 24 ≥ 22 ≥ 17 ≥ 18 ≥ 23 ≥ 18 ≥ 19 ≥ 19 ≥ 17 ≥ 21 ≥ 16 ≥ 17 ≥ 16 ≥ 18 ≥ 20 ≥ 19 ≥ 21



14-22 19-21 16-18 15-18 13-15 15-18 16-20 16-18 15-17 21-23 19-21 13-16 15-17 20-22 15-17 16-18 16-18 15-16 15-20 11-15 13-16 11-15 13-17 17-19 16-18 -



≤ 13 ≤ 18 ≤ 15 ≤ 14 ≤ 12 ≤ 14 ≤ 15 ≤ 15 ≤ 14 ≤ 20 ≤ 18 ≤ 12 ≤ 14 ≤ 19 ≤ 14 ≤ 15 ≤ 15 ≤ 14 ≤ 14 ≤ 10 ≤ 12 ≤ 10 ≤ 12 ≤ 16 ≤ 15 ≤ 20



Streptococcus β Hemolitikus Antibiotik



Penicillin Ampicillin Cefepime Cefotaxime Ceftriaxone Vancomycin Erythromycin Azithromycin Clarithromycin Dirithromycin Tetracycline Levofloxacin Ofloxacin Gatifloxacin Grepafloxacin Trovafloxacin Chloramphenicol Clindamycin Quinupristin-dalfopristin Linezolid



Kriteria Penafsiran Diameter Zona (mm) Sensitif Intermediet Resisten ≥ 24 ≥ 24 ≥ 24 ≥ 24 ≥ 24 ≥ 17 ≥ 21 16-20 ≤ 15 ≥ 18 14-17 ≤ 13 ≥ 21 17-20 ≤ 16 ≥ 18 14-17 ≤ 13 ≥ 23 19-22 ≤ 18 ≥ 17 14-16 ≤ 13 ≥ 16 13-15 ≤ 12 ≥ 21 18-20 ≤ 17 ≥ 19 16-18 ≤ 15 ≥ 19 16-18 ≤ 15 ≥ 21 18-20 ≤ 17 ≥ 19 16-18 ≤ 15 ≥ 19 16-18 ≤ 15 ≥ 21 -



55



C.



Pseudomonas aeruginosa Antibiotik



Piperacillin Ticarcillin Piperacillin-tazobactam Ticarcillin-clavulanic acid Ceftazidime Cefepime Aztreonam Doripenem Imipenem Meropenem Colistin Polymyxin B Gentamicin Tobramycin Amikacin Netilmicin Ciprofloxacin Levofloxacin Lomefloxacin Ofloxacin Norfloxacin Gatifloxacin



D.



Kriteria Penafsiran Diameter Zona (mm) Sensitif Intermediet Resisten ≥ 21 15-20 ≤ 14 ≥ 24 16-23 ≤ 15 ≥ 21 15-20 ≤ 14 ≥ 24 16-23 ≤ 15 ≥ 18 15-17 ≤ 14 ≥ 18 15-17 ≤ 14 ≥ 22 16-21 ≤ 15 ≥ 19 16-18 ≤ 15 ≥ 19 16-18 ≤ 15 ≥ 19 16-18 ≤ 15 ≥ 11 ≤ 10 ≥ 12 ≤ 11 ≥ 15 13-14 ≤ 12 ≥ 15 13-14 ≤ 12 ≥ 17 15-16 ≤ 14 ≥ 15 13-14 ≤ 12 ≥ 21 16-20 ≤ 15 ≥ 17 14-16 ≤ 13 ≥ 22 19-21 ≤ 18 ≥ 16 13-15 ≤ 12 ≥ 17 13-16 ≤ 12 ≥ 18 15-17 ≤ 14



Enterobacteriaceae Antibiotik



Ampicillin Piperacillin Mecillinam Amoxicillin-clavulanic acid Ampicillin-sulbactam Piperacillin-tazobactam Ticarcillin-clavulanate Cefazolin Cephalotin Cefepime Cefotaxime Ceftriaxone Cefotetan Cefoxitin Cefuroxime (parenteral) Ceftazidime Cefamandole Cefmetazole



Kriteria Penafsiran Diameter Zona (mm) Sensitif Intermediet Resisten ≥ 17 14-16 ≤ 13 ≥ 21 18-20 ≤ 17 ≥ 15 12-14 ≤ 11 ≥ 18 14-17 ≤ 13 ≥ 15 12-14 ≤ 11 ≥ 21 18-20 ≤ 17 ≥ 20 15-19 ≤ 14 ≥ 23 20-22 ≤ 19 ≥ 18 15-17 ≤ 14 ≥ 18 15-17 ≤ 14 ≥ 26 23-25 ≤ 22 ≥ 23 20-22 ≤ 19 ≥ 16 13-15 ≤ 12 ≥ 18 15-17 ≤ 14 ≥ 18 15-17 ≤ 14 ≥ 21 18-20 ≤ 17 ≥ 18 15-17 ≤ 14 ≥ 16 13-15 ≤ 12



56 Cefonicid Cefoperazone Ceftizoxime Moxalactam Cefuroxime (oral) Loracarbef Cefacior Cefdinir Cefixime Cefpodoxime Cefprozil Cefetamet Ceftibuten Aztreonam Doripenem Ertapenem Imipenem Meropenem Gentamicin Tobramycin Amikacin Kanamycin Netilmicin Streptomycin Tetracycline Doxycycline Minocycline Ciprofloxacin Levofloxacin Lomefloxacin Ofloxacin Norfloxacin Enoxacin Gatifloxacin Gemifloxacin Grepafloxacin Fleroxacin Cinoxacin Nalidixid acid Trimethoprimsulfamethoxazole Sulfonamides Trimethoprim Chloramphenicol Fosfomycin Nitrofurantoin



≥ 18 ≥ 21 ≥ 25 ≥ 23 ≥ 23 ≥ 18 ≥ 18 ≥ 20 ≥ 19 ≥ 21 ≥ 18 ≥ 18 ≥ 21 ≥ 21 ≥ 23 ≥ 22 ≥ 23 ≥ 23 ≥ 15 ≥ 15 ≥ 17 ≥ 18 ≥ 15 ≥ 15 ≥ 15 ≥ 14 ≥ 16 ≥ 21 ≥ 17 ≥ 22 ≥ 16 ≥ 17 ≥ 18 ≥ 18 ≥ 20 ≥ 18 ≥ 19 ≥ 19 ≥ 19 ≥ 16



15-17 16-20 22-24 15-22 15-22 15-17 15-17 17-19 16-18 18-20 15-17 15-17 18-20 18-20 20-22 19-21 20-22 20-22 13-14 13-14 15-16 14-17 13-14 12-14 12-14 11-13 13-15 16-20 14-16 19-21 13-15 13-16 15-17 15-17 16-19 15-17 16-18 15-18 14-18 11-15



≤ 14 ≤ 15 ≤ 21 ≤ 14 ≤ 14 ≤ 14 ≤ 14 ≤ 16 ≤ 15 ≤ 17 ≤ 14 ≤ 14 ≤ 17 ≤ 17 ≤ 19 ≤ 18 ≤ 19 ≤ 19 ≤ 12 ≤ 12 ≤ 14 ≤ 13 ≤ 12 ≤ 11 ≤ 11 ≤ 10 ≤ 12 ≤ 15 ≤ 13 ≤ 18 ≤ 12 ≤ 12 ≤ 14 ≤ 14 ≤ 15 ≤ 14 ≤ 15 ≤ 14 ≤ 13 ≤ 10



≥ 17 ≥ 16 ≥ 18 ≥ 16 ≥ 17



13-16 11-15 13-17 13-15 15-16



≤ 12 ≤ 10 ≤ 12 ≤ 12 ≤ 14